A review on antibiotics induced nephrotoxicity

One of the common causes acute kidney injury (AKI) is drug nephrotoxicity. AKIs around 20-60% in hospitalised patients are caused by drug-induced nephrotoxicity, which also linked to higher morbidity and death both children adults. Antibiotics one most frequently prescribed classes worldwide and, leading contributors Nephrotoxicity has been related a wide range antimicrobial medications, although characteristics damage vary depending on agent, site toxicity mechanism within renal. Acute tubular necrosis, interstitial nephritis, crystal nephropathy, proximal/distal tubulopathy with electrolyte problems frequent mechanisms. Pre-existing chronic renal disease concurrent use medications nephrotoxic potential two general risk factors for antimicrobial-induced AKI. The various types nephrotoxicity especially antibiotics will be discussed this review offer guidance how prevent AKI recognize it early order reduce morbidity.